Stable HIV-1 envelope glycoprotein immune complexes as vaccine immunogens
نویسندگان
چکیده
منابع مشابه
Envelope Glycoprotein Trimers as HIV-1 Vaccine Immunogens
The HIV-1 envelope glycoprotein spike is the target of neutralizing antibody attack, and hence represents the only relevant viral antigen for antibody-based vaccine design. Various approaches have been attempted to recapitulate Env in membrane-anchored and soluble forms, and these will be discussed here in the context of recent successes and challenges still to be overcome.
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Cytokines are often used as adjuvants to increase the immunogenicity of vaccines because they can improve the immune response and/or direct it into a desired direction. As an alternative to codelivering Ags and cytokines separately, they can be fused into a composite protein, with the advantage that both moieties act on the same immune cells. The HIV-1 envelope glycoprotein (Env) spike, located...
متن کاملStabilized HIV-1 envelope glycoprotein trimers for vaccine use
PURPOSE OF REVIEW To provide an update on the latest developments in the field of HIV-1 antibody-based soluble envelope glycoprotein (Env) trimer design for vaccine use. RECENT FINDINGS The development of soluble native-like HIV-1 Env trimer immunogens has moved the field of antibody-based vaccine design forward dramatically over the past few years with refinement of various stabilizing appro...
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HIV-1 displays the most genetic diversity of any virus studied to date [1]. Within an infected individual, the virus constantly mutates, outpacing host immune responses and increasing the number of distinct isolates that may be transmitted. Contending with such extreme diversity poses an unprecedented challenge for HIV-1 vaccine development. Although few HIV-1 preventive vaccine efficacy trials...
متن کاملHIV-1 ENVELOPE. Effect of the cytoplasmic domain on antigenic characteristics of HIV-1 envelope glycoprotein.
A major goal for HIV-1 vaccine development is the production of an immunogen to mimic native, functional HIV-1 envelope trimeric spikes (Env) on the virion surface. We lack a reliable description of a native, functional trimer, however, because of inherent instability and heterogeneity in most preparations. We describe here two conformationally homogeneous Envs derived from difficult-to-neutral...
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ژورنال
عنوان ژورنال: Retrovirology
سال: 2011
ISSN: 1742-4690
DOI: 10.1186/1742-4690-8-s2-p75